Somatic Cancer
Solid Tumors
SHOP PRODUCTS
Clinical implementation of NGS-based tumor profiling assays is greatly expedited with the use of clinically relevant reference samples with the requisite breadth of genomic alterations and resemblance to patient samples. Seraseq™ tumor profiling reference materials are highly multiplexed positive sample controls, engineered from a blend of biosynthetic targets and well-characterized wild-type background genomic DNA. These materials support molecular diagnostic labs in accelerating the use of NGS technology in clinical diagnosis and biomarker-based therapeutic guidance for various cancer diseases.
Actionable variants to optimize and challenge your assay
- Expert-designed constructs with clinically relevant variants
- Highly multiplexed with up to 40 variants or 18 gene fusions in a single reference material
- Coverage across broad variant types - SNVs, INDELs, CNVs, and gene fusions
- Multiple formats - purified DNA, purified RNA, or FFPE.
- Customizable and flexible content
- Manufactured in GMP-compliant and ISO 13485-certified facilities
Gene List - Tumor DNA
| AKT1 |
CTNNB1 |
FLT3 |
GNAS |
KRAS |
NRAS/CSDE1 |
RET |
| APC |
EGFR |
FOXL2 |
IDH1 |
MPL |
PDGFRA |
SMAD4 |
| ATM |
ERBB2 |
GNA11 |
JAK2 |
NCOA4-RET |
PIK3CA |
TP53 |
| BRAF |
FGFR3 |
GNAQ |
KIT |
NPM1 |
PTEN |
TPR-ALK |
Gene List - Fusion RNA
| CCDC6-RET |
EML4-ALK |
KIF5B-RET |
PAX8-PPARG1 |
TMPRSS2-ERG |
EGFR-SEPT14 |
| CD74-ROS1 |
ETV6-NTRK3 |
LMNA-NTRK1 |
SLC34A-ROS1 |
TPM3-NTRK1 |
FGFR3-TACC3 |
| EGFR Variant III |
FGFR3-BAIAP2L1 |
MET ex14 Skipping |
SLC45A3-BRAF |
NCOA4-RET |
TFG-NTRK1 |
Gene List - Whole Transciptome RNA Seq
| BCR-ABL1 |
ETV6-NTRK3 |
MET ex 14 Skipping |
SLC45A3-BRAF |
| CCDC6-RET |
FGFR3-TACC3 |
NACC2-NTRK2 |
TCF3-PBX1 |
| CD74-ROS1 |
KIF5B-RET |
NCOA4-RET |
TMPRSS2-ERG |
| EML4-ALK |
LMNA-NTRK1 (transcript 1) |
PML-RARα |
TPM3-NTRK1 |
| ETV6-ABL1 (transcript 1) |
LMNA-NTRK1 (transcript 2) |
RUNX1-RUNX1T1 |
|
| ETV6-ABL1 (transcript 2) |
MEF2D-CSF1R |
SLC34A2-ROS1 |
|
Next-Generation Sequencing Assay Validation: A Practical Guide for the Clinical Genomics Laboratory
Focuses on the process for NGS assay validation and will walk through key considerations and guidelines you can follow to ensure a smooth and successful implementation.
Next-generation sequencing (NGS) has revolutionized the field of genomics and how in vitro diagnostic (IVD) test developers, laboratories, and clinicians are diagnosing, treating, and monitoring disease. Before you can successfully launch a clinical assay, platform, or service, you need to be absolutely confident that the test has gone through rigorous development and thorough validation to ensure accuracy of the result.
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