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Controls & Reference Materials

Seraseq® gDNA TMB Reference Panel Mix

Material Number 0710-2463
Size 5 x 20 µL
Inventory Status In Stock
Unit EA
The level of somatic mutations in a tumor, called tumor mutational burden (TMB), is used as a biomarker to predict patient response to immune checkpoint inhibitor therapy, with cancer type-specific TMB cut-offs of clinical value. Whole exome sequencing (WES) has been the gold standard to measure TMB. While targeted panels have the capacity to estimate TMB, TMB scores can vary significantly depending on the panel size, coverage regions, and bioinformatics pipeline used to make variant calls. LGC SeraCare has developed Seraseq gDNA TMB Reference Panel Mix, which has been extensively validated using WES and can be used to guide TMB score assessment using targeted panels, especially around values that may be clinical decision points for different tumor types. Each Seraseq gDNA TMB Reference Panel Mix contains five vials of purified genomic DNA from tumor-like human cell lines encompassing complex genomic signatures over a broad range of TMB scores, all in one kit.

Seraseq gDNA TMB Reference Panel Mix

Doc type
Data Sheet

Seraseq gDNA TMB Reference Panel Mix Package Insert

Doc type
Package Insert

Seraseq gDNA TMB Reference Panel Mix

Doc type
Technical Product Report
Lot #
10615103

Seraseq gDNA TMB Reference Panel Mix Product Sheet

Doc type
Product Sheet