Immuno-oncology
Seraseq® gDNA TMB Reference Panel Mix
Material Number
0710-2463
Size
5 x 20 μL
Inventory Status
In Stock
Unit
EA
Details
Resources
Frequently Asked Questions
The level of somatic mutations in a tumor, called tumor mutational burden (TMB), is used as a biomarker to predict patient response to immune checkpoint inhibitor therapy, with cancer type-specific TMB cut-offs of clinical value. Whole exome sequencing (WES) has been the gold standard to measure TMB. While targeted panels have the capacity to estimate TMB, TMB scores can vary significantly depending on the panel size, coverage regions, and bioinformatics pipeline used to make variant calls. LGC SeraCare has developed Seraseq gDNA TMB Reference Panel Mix, which has been extensively validated using WES and can be used to guide TMB score assessment using targeted panels, especially around values that may be clinical decision points for different tumor types. Each Seraseq gDNA TMB Reference Panel Mix contains five vials of purified genomic DNA from tumor-like human cell lines encompassing complex genomic signatures over a broad range of TMB scores, all in one kit.
Seraseq gDNA TMB Reference Panel Mix
Doc type
Data Sheet
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Seraseq gDNA TMB Reference Panel Mix Product Sheet
Doc type
Product Sheet
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Seraseq gDNA TMB Non-Requirement Letter
Doc type
Safety Data Sheet (Non-Requirement Letter)
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Seraseq gDNA TMB Reference Panel Mix Non-Requirement Letter
Doc type
Safety Data Sheet (Non-Requirement Letter)
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Seraseq gDNA TMB Reference Panel Mix Package Insert
Doc type
Package Insert
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Seraseq gDNA TMB Reference Panel Mix
Immuno-oncology FAQs
Review the common questions we receive from our customers and the responses we provide.