New
Clinical Lab Quality Control
Accukit™ ctDNA MRD IS
Material Number
AG-2091
Size
1 x 10 uL
Inventory Status
Backorder: Available Soon
Unit
EA
Details
Specifications
The Accukit™ ctDNA MRD IS product is a reference material co-developed with LGC Diagnostics and Genomics Innovation Hub that is spiked into each sample in Next Generation Sequencing (NGS) assays that detect somatic mutations in human cancer patient samples. This product is intended for use as a quality control material in the development, validation and routine testing of laboratory tests used to monitor cancer disease progression or treatment response by ctDNA NGS assays. Product is manufactured for Research Use
Only (RUO). Not for use in diagnostic procedures.
LGC is proud to be the exclusive distributor for North America, UK and Europe.
| Table 1: List of mutations present in Accukit™ ctDNA MRD IS, along wit the clinically relevant neat adjacent mutation. | ||||||
| Gene | Nucleotide Change | Amino Acid | GRCh37Location | Near Adjacent Mutation | ||
| 1 | AKT1 | c.63G>T | p.T21 | 14:105246537 | p.F17K | |
| 2 | ALK | c.3534G>A | p.N1178 |
2:29443683 |
p.F1174L | |
| 3 | ALK | c.3618G>A | p.S1206 | 2:29443599 | p.G1202R | |
| 4 | BRAF | c.1806A?T | p.S602 | 7:140453129 | p.V600E | |
| 5 | EGFR | c.2213_2227del | p.V738_V742del | 7:55242443_55242457 | p.E746_A750del | |
| 6 | EGFR | c.2376C>G | p.L792 | 7:55249078 | p.T790M | |
| 7 | EGFR | c.2562A>C | p.T854 | 7:55259504 | p.L858R | |
| 8 | KRAS | c.33A>G | p.A11 | 12:25398286 | p.G12C | |
| 9 | NRAS | c.180T>C | p.G60 | 1:115256531 | p.Q61R | |
| 10 | PIK3CA | c.3147T>A | p.G1049 | 3:178952092 | p.H1047R | |